Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi.

Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

Intracellular pathogens employ several strategies for iron acquisition from host macrophages for survival and growth, whereas macrophage resists infection by actively sequestering iron. Here, we show that instead of allowing macrophage to sequester iron, protozoan parasite Leishmania donovani (LD) uses a novel strategy to manipulate iron uptake mechanisms of the host and utilizes the taken up i...

Affinities of Treponema pallidum for human lactoferrin and transferrin.

The acquisition of lactoferrin and transferrin by live Treponema pallidum organisms was examined. Saturation binding kinetics were obtained for virulent treponemes with increasing amounts of radioiodinated lactoferrin but not with transferrin. Furthermore, lactoferrin bound up to 100 times more effectively than transferrin. Only unlabelled lactoferrin stoichiometrically completed with iodinated...

Evidence of transferrin binding sites on the surface of Leishmania promastigotes.

A glycoprotein of 78,000 molecular mass (78 kDa), associated with the membrane of Leishmania infantum promastigotes, was identified and immunopurified by monoclonal antibody (mAb) LD9 produced against isolated membrane preparations. mAb LD9 was subsequently found to bind to human transferrin, also of 78 kDa. Binding of LD9 to transferrin was completely abolished when the mAb was preabsorbed by ...

Cells from Transferrin and Lactoferrin by Myeloid Multivalent Metal-Induced Iron Acquisition

Molecular Docking Analysis of Human Transferrin and Lactoferrin Binding Proteins of Neisseria Meningitidis with 5 Hydroxy 1-4 Naphthoqinone

Neisseria meningitidis is the principal cause of bacterial meningitis.. Bacteria can be transmitted by carriers through the droplets of respiratory secretions and can only infect humans. The mortality rate of bacterial meningitis is very high even after the discovery of many antibiotics. Acquisition of iron is the major determinant in the pathogenesis of Neisseria meningitidis which is fulfille...